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Irbesartan stops angiotensin II binding to your AT1 receptor in tissues like vascular sleek muscle mass and the adrenal gland. Irbesartan and its Energetic metabolite bind the AT1 receptor with 8500 occasions additional affinity than they bind on the AT2 receptor.
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Irbesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding into the AT1 angiotensin II receptor. You can find also an AT2 receptor in lots of tissues, but It is far from linked to cardiovascular homeostasis.
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The renin-aldosterone website link is mediated by angiotensin II, so coadministration of an angiotensin II receptor antagonist has a tendency to reverse the potassium decline linked to these diuretics.
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